Graduation
Application
We appreciate your interest in our Institute. Even if there are no available graduation topics explicitly listed below, we welcome your unsolicited application.
3x Wissenschaftlicher Mitarbeiterin (m/w/d)
1x PostDoc position (E13 TV-L, 100%, befristet)
2x PhD position (E13 TV-L, 75%, befristet)
The TissueRegenerator project is dedicated to the development of new quality standards in tissue engineering, in particular for the automated production and quality control of regenerated skeletal muscle tissue. We want to establish an innovative technology for non-invasive real-time quality control and enable technology transfer into clinical practice.
The overall aim of the project is to develop a standardized and automated process for the production and regeneration of skeletal muscle tissue from cell-free scaffolds, or for the production of cell-free muscle matrices from extracellular matrix (so-called muscle patches to aid regeneration in case of muscle loss). This is a decisive step towards enabling the clinical application of such tissues. The focus is on replacing the previous limitations of invasive quality controls with non-contact, non-destructive methods and optimizing process control through innovative control technology.
Detailed Stellenbeschreibung
MyoRobot 3.0
i) Implementing intelligent Analysis algorithms for biomechanics data (BA / MA)
ii) Establishing fluorescence optics and biological validation (BA / MA) – currently unavailable
iii) GUI and backend development (homogenize and develop scalable LabVIEW source code) (MA)
iv) Rework the mechanical setup based on good manufacturing practices in civil engineering to improve robustness and precision (MA) [PDF]
v) Automating stretch-correction via image detection/correlation or object tracking (MA)
vi) Implementing auto-focus functionality, e.g., through contrast maximization methods (MA)
vii) Impact of repeated eccentric contractions to the calcium sensitivity of the muscle as protective mechanism & titn’s contribution to residual force enhancement in muscle fibres (MA)
viii) Building a ventilated light proof black box to block stray light and filter dust particles and validate its effectiveness via stretch experiments at different speeds (visco-elastic properties of muscle) (BA/MA)
All work packages can be tailored to specific needs/wishes, freely combined and can include biological/physiologically-themed questions on muscle fibre biomechanics
For further information please contact Dr. Michael Haug
