Publications

  1. Ghanbari MH, Biesalski M, Friedrich O, Etzold B (2024) Screen printed 3D Microfluidic Paper-based and Modifier-Free Electroanalytical Device for Clozapine Sensing. Analyst, in press. (doi: )
  2. Ghanbari MH, Biesalski M, Friedrich O, Etzold B (2024) Clozapine sensing through paper-based microfluidic sensors directly modified via electro-deposition and electro-polymerization. Sensors Diagnostics, in press. (doi: 10.1039/D4SD00252K)
  3. Buehler A, Brown E, Nedoschill E, Eckstein M, Ludwig P, Raming R, Oraiopoulou ME, Paulus LP, Rother U, Friedrich O, Neurath MF, Woelfle J, Waldner MJ, Knieling F, Bohndiek SE, Regensburger AP (2024)
    In vivo assessment of deep vascular patterns in murine colitis using Optoacoustic Mesoscopic Imaging. Adv Sci 11(45): 2404618. (doi: 10.1002/advs.202404618)
  4. Schmid R, Schipka R, Heltmann-Meyer S, Schneidereit D, Friedrich O, Röder J, Boccaccini AR, Schrüfer S, Schubert DW, Horch R, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A (2024) Characterization of two different alginate-based bioinks and the influence of melanoma growth within. Sci Rep 14(1):12945. (doi: 10.1038/s41598-024-63642-3)
  5. Haug M, Michael M, Ritter P, Kovbasyuk L, Vazakidou ME, Friedrich O (2024) Levosimendan’s effects on length-dependent activation in murine fast-twitch skeletal muscle. Int J Mol Sci  25:6191. (doi: 10.3390/ijms25116191)
  6. Schneidereit D, Bauer J, Mnuskina S, Nübler S, Cacciani N, Mühlberg A, Kreiss L, Ritter P, Schürmann S, Larsson L, Friedrich O (2024) CAS3D: 3D Quantitative Morphometry on Second Harmonic Generation Image volumes from Single Skeletal Muscle Fibers. Comput Biol Med 178:108618. (doi: 10.1016/j.compbiomed.2024.108618)
  7. Haug M*, Schwappacher R*, Pollmann C*, Ritter P, Michael M, Hermann H, Grützmann R, Mittelstädt A, Neurath M, Zopf Y*, Friedrich O* (2024) Effects of adjuvant exercise and nutrition therapy on muscle fibre biomechanics in gastrointestinal cancer patients. Cancers 16:1608. (doi: 10.3390/cancers16081608 )
  8. Merten AL, Schöler U, Guo Y, Linsenmeier F, Martinac B, Friedrich O, Schürmann S (2024) High-content method for mechanosignaling studies using IsoStretcher technology and quantitative Ca2+ imaging applied to Piezo1 in cardiac HL-1 cells. Cell Mol Life Sci 81:140. (doi: 10.1007/s00018-024-05159-6)
  9. Xu S, Yang X, Ritter P, Dai X, Lee KC, Kreiss L, Zhou KC, Kim K, Chaware A, Neff J, Glass C, Lee SA, Friedrich O, Horstmeyer R (2024) Tensorial tomographic Fourier Ptychography with applications to muscle tissue imaging. Adv Photonics 6(2):026004 (doi: 10.1117/1.AP.6.2.026004)
  10. Herrmann L, Leidenberger M, Quadros HC, Grau BW, Hampel F, Friedrich O, Moreira DRM, Kappes B, Tsogoeva S (2024) Access to Artemisinin-Triazole Antimalarials via Organo-Click Reaction: High In Vitro/In Vivo Activity Against Multidrug-Resistant Malaria Parasites. JACS Au 4(3):951-957. (doi: 10.1021/jacsau.3c00716)
  11. Merten AL, Schöler U, Lesko C, Kreiß L, Schneidereit D, Linsenmeier F, Stolz A, Rappl S, Ali M, Potie, Ahmed A, Morales-Dalmau J, Saam J, Schürmann S, Friedrich O (2024) A Novel Modular Opto-Biomechatronics Bioreactor for Simultaneous Isotropic Mechanical Stretch Application and Fluorescence Microscopy under Cell and Tissue Culture Conditions. Biosens Bioelectron X 16:100437. (doi: 10.1016/j.biosx.2024.100437)

 

  1. Niloy SI, Strege P, Hannan E, Cowan L, Linsenmeier F, Friedrich O, Farrugia G, Beyder A (2023) Stretch response of the mechano-gated channel TMEM63A in membrane patches and single cells. Am J Physiol Cell Physiol 326(2):C622-C631. (doi: 10.1152/ajpcell.00583.2023)
  2. Schulz-Kuhnt A, Rühle K, Javidmehr A, Döbrönti M, Biwank J, Knittel S, Neidlinger P, Leupold J, Liu LJ, Dedden M, Taudte RV, Gessner A, Fromm MF, Mielenz D, Kreiss L, Waldner M, Schürmann S, Friedrich O, Dietel B, López-Posadas R, Plattner C, TRR241 IBDome Consortium, Zundler S, Becker C, Atreya R, Neurath MF, Atreya (2023) ATP Citrate Lyase (ACLY)-dependent immunometabolism in mucosal T cells drives experimental colitis in vivo. Gut 73(4):601-612. (doi: 10.1136/gutjnl-2023-330543)
  3. Kopecky C, Haug M, Reischl B, Deshpande N, Manandhar B, King TW, Lee V, Wilkins MR, Morris M, Polly P, Friedrich O, Rye KA, Cochran BJ (2023) Effect of insulin insufficiency on ultrastructure and function in skeletal muscle. J Cachexia Sarcopenia Muscle 15(1): 112-123. (doi: 10.1002/jcsm.13380)
  4. Kreiss L, Jiang S, Li X, Xu S, Zhou KC, Lee KC, Mühlberg A, Kim K, Chaware A, Ando M, Barisoni L, Lee SA, Zheng G, Lafata K, Friedrich O, Horstmeyer R (2023) Digital staining in optical microscopy using deep learning – a review. PhotoniX 4: 34. (doi: 10.1186/s43074-023-00113-4)
  5. Mühlberg A, Ritter P, Langer S, Goossens C, Nübler S, Schneidereit D, Taubmann O, Denzinger F, Nörenberg D, Haug M, Schürmann S, Horstmeyer R, Maier AK, Goldmann WH, Friedrich O, Kreiss L (2023) SEMPAI: a Self-Enhancing Multi-Photon Artificial Intelligence for prior-informed assessment of muscle function and pathology. Adv Sci 10: 2206319. (doi: 10.1002/advs.202206319)
  6. Polley C, Distler T, Scheufler C, Detsch R, Lund H, Springer A, Schneidereit D, Friedrich O, Boccaccini AR, Seitz H (2023) 3D printing of piezoelectric and bioactive barium titanate-bioactive glass scaffolds for bone tissue engineering. Bioactive Materials 21:100719. (doi: 10.1016/j.mtbio.2023.100719)
  7. Rederer A, Rose V, Krüger R, Schmittutz L, Swierzy T, Fischer L, Thievessen I, Bauer J, Friedrich O, Schiffer M, Müller-Deile J (2023) Partner, neighbor, housekeeper and dimension: 3D versus 2D glomerular co-cultures reveal drawbacks of currently used cell culture models. Int J Mol Sci 24: 10384. (doi: 10.3390/ijms241210384)
  8. Kahl M, Schneidereit D, Meinert C, Bock N, Hutmacher DW, Friedrich O (2023) A fluorescence-based opto-mechatronic screening module (OMSM) for automated 3D cell culture workflows. Biosens Bioelectron X 14: 100372. (doi: 10.1016/j.biosx.2023.100372)
  9. Mnuskina S*, Bauer J*, Wirth-Hücking A, Schneidereit D, Nübler S, Ritter P, Cacciani N, Li M, Larsson L, Friedrich O (2023) Single fibre cytoarchitecture in Ventilator-induced Diaphragm Dysfunction (VIDD) assessed by quantitative morphometry Second Harmonic Generation imaging: positive effects of BGP-15 chaperone co-inducer and VBP-15 dissociative corticosteroid treatment. Front Physiol 14: 1207802. (doi: 10.3389/fphys.2023.1207802)
  10. Sommer K, Heidbreder K, Kreiss L, Dedden M, Paap EM, Wiendl M, Becker M, Atreya R, Müller TM, Atreya I, Waldner M, Schürmann S, Friedrich O, Neurath MF, Zundler S (2023) Anti-β7 integrin treatment impedes the recruitment on non-classical monocytes to the gut and delays macrophage-mediated intestinal wound healing. Clin Transl Med 13(4): e1233. (doi: 10.1002/ctm2.1233)
  11. Friedrich O, Gilbert DF (Edts) (2023) Cell Viability Assays (2nd Edition). In: Meth Mol Biol 2644, Springer Protocols. Springer Nature, Humana Press, New York. (doi: 10.1007/978-1-0716-3052-5)
  12. Gilbert DF, Friedrich O, Wiest J (2023) Assaying Proliferation Characteristics of Cells Cultured Under Static Versus Periodic Conditions. In: Cell Viability Assays (2nd Edition), Meth Mol Biol 2644, Springer Protocols. Springer Nature, Humana Press, New York. pp. 35-45. (doi: 10.1007/978-1-0716-3052-53)
  13. Schöler U, Merten AL, Schürmann S, Friedrich O (2023) Quantitative Live-Cell Ca2+ Imaging During Isotropic Cell Stretch. In: Cell Viability Assays (2nd Edition), Meth Mol Biol 2644, Springer Protocols. Springer Nature, Humana Press, New York. pp. 155-176. (doi: 10.1007/978-1-0716-3052-510)
  14. Bauer J, Head SI, Friedrich O (2023) Assessment of Cell Viability in Electrically Excitable Muscle Cells Through Intact Twitch Stimulation. In: Cell Viability Assays (2nd Edition), Meth Mol Biol 2644, Springer Protocols. Springer Nature, Humana Press, New York. pp. 177-192. (doi: 10.1007/978-1-0716-3052-511)
  15. Schneidereit D, Nübler S, Friedrich O (2023) Second Harmonic Generation Morphometry of Muscle Cytoarchitecture in Living Cells. In: Cell Viability Assays (2nd Edition), Meth Mol Biol 2644, Springer Protocols. Springer Nature, Humana Press, New York. pp. 267-285. (doi: 10.1007/978-1-0716-3052-517)
  16. Krolinski A, Sommer K, Wiesner J, Friedrich O, Vielreicher M (2023) Optimized Method of 3D Scaffold Seeding, Cell Cultivation, and Monitoring Cell Status for Bone Tissue Engineering. In: Cell Viability Assays (2nd Edition), Meth Mol Biol 2644, Springer Protocols. Springer Nature, Humana Press, New York. pp. 467-480. (doi: 10.1007/978-1-0716-3052-530)
  17. Buehler A, Brown E, Paulus LP, Eckstein M, Thoma OM, Oraiopoulou ME, Rother U, Hörning A, Hartmann A, Neurath MF, Woelfle J, Friedrich O, Waldner MJ, Knieling F, Bohndiek SE, Regensburger AP (2023) Transrectal Absorber Guide Raster-Scanning Optoacoustic Mesoscopy for Label-Free in vivo Assessment of Colitis. Adv Sci 10: 2300564. (doi: 10.1002/advs.202300564)
  18. Herrmann L, Leidenberger M, de Morais A S, Mai C, Capci A, da Cruz M, Borges S, Plass A, Kahnt A, Moreira D R M, Kappes B, Tsogoeva S B (2023) Autofluorescent antimalarials by hybridization of artemisinin and coumarin: In vitro/in vivo studies and live-cell imaging. In: Chemical Science (accepted)

  1. Kratzer S, Arkudas A, Himmler M, Schubert DW, Schneidereit D, Bauer J, Friedrich O, Horch RE, Cai A (2022) Vascularization of Poly-ϵ-Caprolactone-Collagen I-Nanofibers with or without Sacrificial Fibers in the Neurotized Arteriovenous Loop Model. Cells 11: 3774. (doi: 10.3390/cells11233774)
  2. Ginestea C, Youhanna S, Vorrink SU, Henriksson S, Hernandez A Cheng AJ, Chaillou T, Buttgereit A, Schneidereit D, Friedrich O, Hultenby K, Bruton JD, Ivarsson N, Sandblad L, Lauschke VM,Westerblad H (2022) Collagenase-mediated cell dissociation alters gene expression patterns and causes loss of mitochondrial Ca2+ control in skeletal muscle fibers. iScience 25(12): 105654. (doi: 10.1016/j.isci.2022.105654)
  3. Michael M, Kovbasyuk L, Ritter P, Reid MB, Friedrich O, Haug M (2022) Redox Balance differentially affects biomechanics in permeabilized single muscle fibres – active and passive force assessments with the MyoRobot. Cells 11: 375. (doi: 10.3390/cells11233715)
  4. Ritter P, Nübler S, Buttgereit A, Smith LR, Mühlberg A, Bauer J, Michael M, Kreiss L, Haug M, Barton ER*, Friedrich O* (2022) Myofibrillar lattice remodeling is a structural cytoskeletal predictor of diaphragm muscle weakness in a fibrotic mdx (mdx Cmah-/-) model. Int J Mol Sci 23: 10841. (doi: 10.3390/ijms231810841)
  5. Kara A, Distler T, Polley C, Schneidereit D, Seitz H, Friedrich O, Tihminlioglu F, Boccaccini AR (2022) 3D-Printed Gelatin/Decellularized Bone Composite Scaffolds for Bone Tissue Engineering: Fabrication, Characterization and Cytocompatibility Study. Mater Today Bio 15: 100309. (doi: 10.1016/j.mtbio.2022.100309)
  6. Kreiß L*, Ganzleben I*, Mühlberg A, Ritter P, Schneidereit D, Becker C, Neurath MF, Friedrich O, Schürmann S, Waldner M (2022) Label-free analysis of inflammatory tissue remodeling in murine lung tissue via multiphoton microscopy, Raman spectroscopy and machine learning. J Biophotonics 2022: e3010. (doi: 10.1002/jbio.202200073) Cover artwork Issue 09/22, https://www.onlinelibrary.wiley.com/toc/18640648/2022/15/9
  7. Ryma M, Genc H, Nadernezhad A, Paulus I, Schneidereit D, Friedrich O, Andelovic K, Lyer S, Alexiou C, Cicha I, Groll J (2022) A print-and-fuse strategy for sacrificial filaments enables biomimetically structured perfusable microvascular networks with functional endothelium inside 3D hydrogels. Adv Mater 34(28): e2200653. (doi: 10.1002/adma.202200653)
  8. Kunze P*, Kreiß L*, Novosadova V, Roehe A, Steinmann S, Prochazka J, Geppert CI, Hartmann A, Schürmann S, Friedrich O*, Schneider-Stock R* (2022) Multiphoton microscopy reveals host extracellular matrix remodeling in a chorioallantoic membrane (CAM) model. Cancers 14: 2364. (doi: 10.3390/cancers14102364)
  9. Kreiß L, Thoma OA, Lemire S, Lechner K, Carle B, Dilipkumar A, Kunert T, Scheibe K, Heichler C, Merten AL, Weigmann B, Neufert C, Hildner K, Vieth M, Neurath MF, Friedrich O, Schürmann S*, Waldner MJ* (2022) Label-free characterization and quantification of mucosal inflammation in common murine colitis models with multiphoton imaging. Inflam Bowel Dis 28(11): 1637-1646. (doi: 10.1093/ibd/izac114)
  10. Haug M, Reischl B, Nübler S, Kiriaev L, Mazala DAG, Houweling PJ, North KN, Friedrich O*, Head SI* (2022) Absence of the Z-disc protein α-actinin-3 impairs the mechanical stability of Actn3KO mouse fast-twitch muscle fibres without altering their contractile properties or twitch kinetics. Skeletal Muscle 12: 14. (doi: 10.1186/s13395-022-00295-8)
  11. Lemire S, Thoma OM, Kreiss L, Völkl S, Friedrich O, Neurath MF, Schürmann S, Waldner MJ (2022) Natural NADH and FAD autofluorescence as label-free biomarkers for discriminating subtypes and functional states of immune cells. Int J Mol Sci 22: 2338. (doi: 10.3390/ijms23042338)
  12. Simon N, Voigtländer C, Kappes R, Rohrbach P*, Friedrich O* (2022) PfMDR1 transport rates assessed in intact isolated Plasmodium falciparum digestive vacuoles reflect functional drug resistance relationship with pfmdr1 mutations. Pharmaceuticals 15(2): 202. (doi: 10.3390/ph15020202)
  13. Ritter P, Cai A, Reischl B, Fiedler M, Prölß G, Frieß B, Kretzschmar E, Michael M, Hartmann K, Lesko C, Saiti H, Arkudas A, Horch R, Paulsen F, Friedrich O, Haug M (2022) MyoBio: an automated bioreactor system technology for standardized perfusion-decellularization of whole muscle. IEEE Trans Biomed Eng 69(7): 2305-2313. (doi: 10.1109/TBME.2022.3142317)

  1. Spörrer M, Kah D, Gerum RC, Reischl B, Huraskin D, Dessalles CA, Schneider W, Goldmann WH, Herrmann H, Thievessen I, Clemen CS, Friedrich O, Hashemolhosseini S, Schröder R, Fabry B (2021) The desmin mutation R349P increases contractility and fragility of stem cell-generated muscle micro-tissues. Neuropathol Appl Neurobiol 48: e12784. (doi: 10.1111/nan.12784)
  2. Schmid R, Schmidt SK, Detsch R, Horder H, Blunk T, Schrüfer S, Schubert DW, Fischer L, Thievessen I, Heltmann-Meyer S, Steiner D, Schneidereit D, Friedrich O, Grüneboom A, Amouei H, Wajant H, Horch RE, Bosserhoff AK, Arkudas A, Kengelbach-Weigand A (2021) A new printable alginate / hyaluronic acid / gelatin hydrogel suitable for biofabrication of in vitro and in vivo metastatic melanoma models. Adv Funct Mater 2021: 2108993. (doi: 10.1002/adfm.202107993)
  3. Martonova D, Alkassar M, Seufert J, Holz D, Tuan Duong M, Reischl B, Friedrich O, Leyendecker S (2021) Influence of passive mechanical properties in healthy and infarcted rat myocardium on the cardiac cycle. Proc Appl Math Mech 21(1): e202100054. (doi: 10.1002/pamm.202100054)
  4. Kahl M, Schneidereit D, Bock N, Friedrich O, Hutmacher DW, Meinert (2021) MechAnalyze – an algorithm for standardization and automation of compression test analysis. Tissue Eng Pt C 27(10): 529-542. (doi: 10.1089/ten.tec.2021.0170)
  5. Heltmann-Meyer S, Steiner D, Müller C, Schneidereit D, Friedrich O, Salehi S, Engel FB, Arkudas A, Horch RE (2021) Gelatin methacryloyl is a slow degrading material allowing vascularization and long-term use in vivo. Biomed Mater 16(6): 065004. (doi: 10.1088/1748-605X/ac1e9d)
  6. Haug M, Ritter P, Michael M, Reischl B, Schürmann S, Prölß G, Friedrich O (2021) Structure-Function Relationships in Muscle Fibres: MyoRobot online Assessment of Muscle Fibre Elasticity and Sarcomere Length Distributions. IEEE Trans Biomed Eng 69(1): 148-155. (doi: 10.1109/TBME.2021.3089739)
  7. Vielreicher M, Bozec A, Schett G, Friedrich O (2021) Murine metatarsus bone and joint collagen-I fiber morphologies and networks studied with SHG multiphoton imaging. Front Bioeng Biotechnol 9: 608383. (doi: 10.3389/fbioe.2021.608383)
  8. Goossens C, Weckx R, Derde S, Van Helleputte L, Schneidereit D, Haug M, Reischl B, Friedrich O, Van Den Bosch L, Van den Berghe G, Langouche L (2021) Impact of prolonged sepsis on neural and muscular components of muscle contractions in a mouse model. J Cachexia Sarcopeni 12: 443-455. (doi: 10.1002/jcsm.12668)
  9. Zimmermann T, Gebhardt LA, Kreiss L, Schneider C, Arndt S, Karrer S, Friedrich O, Fischer MJM, Bosserhoff AK (2021) Acidified nitrite contributes to the antitumor effect of cold atmospheric plasma on melanoma cells. Int J Mol Sci 22: 3757. (doi: 10.3390/ijms22073757)
  10. Gilbert DF, Friedrich O, Lesko C, Hartmann K (2021) DIY-Werkzeuge. Hilfsmittel und Verfahren für zellbasiertes high content imaging. Biospektrum 27: 157-159. (doi: 10.1007/s12268-021-1542-3)
  11. Eggert S, Kahl M, Bock N, Meinert C, Friedrich O, Hutmacher DW(2021) An open-source technology platform to increase reproducibility and enable highthroughput production of tailorable gelatin methacryloy (GelMA)-based hyrogels. Mater Design 204: 109619. (doi: 10.1016/j.ohx.2020.e00152)
  12. Distler T, Polley C, Shi F, Schneidereit D, Ashton MD, Friedrich O, Koln JF, Hardy JG, Detsch R, Seitz H, Boccaccini AR (2021) Electrically Conductive and 3D-printable Oxidized Alginate-Gelatin Polypyrrole:PSS Hydrogels for Tissue Engineering. Adv Healthcare Mater 2021: 2001876. (doi: 10.1002/adhm.202001876)
  13. Martonova D, Alkassar M, Seufert J, Holz D, Tuan Dong M, Reischl B, Friedrich O, Leyendecker S (2021) Characterisation of passive mechanical properties in healthy and infarcted rat myocardium. J Mech Behav Biomed Mater 119: 104430. (doi: 10.1016/j.jmbbm.2021.104430)
  14. Distler T, Kretzschmar L, Schneidereit D, Girardo S, Goswami R, Friedrich O, Detsch R, Guck J, Boccaccini AR, Budday S (2021) Mechanical properties of cell- and microgel bead-laden oxidized alginate-gelatin hydrogels. Biomater Sci 9(8): 3051-3068. (doi: 10.1039/d0bm02117b)
  15. Kah D, Winterl A, Prechova M, Schöler U, Schneider W, Friedrich O, Gregor M, Fabry B (2020) A low-cost uniaxial cell stretcher for six parallel wells. Hardware X 9: e00162. (doi: 10.1016/j.ohx.2020.e00162)
  16. Guo Y, Merten AL, Schöler U, Yua ZY, Cvetkovskaa J, Fatkin D, Feneley MP, Martinac B, Friedrich O (2021) In vitro cell stretching technology (IsoStretcher) as an approach to unravel Piezo1-mediated cardiac mechanotransduction. Prog Biophys Mol Biol 159: 22-33. (doi: 10.1016/j.pbiomolbio.2020.07.003)
  17. Dakhil H, Basu S K, Steiner S, Gerlach Y, Soller A, Pan S, German N, Leidenberger M, Kappes B, Wierschem A, Buffered λ-DNA solutions at high shear rates. In: Journal of Rheology 65 (2021), p159-169 (doi:10.1122/8.0000136)

  1. Schneidereit D, Bröllochs A, Ritter P, Kreiß L, Mokhtari Z, Beilhack A, Krönke G, Ackermann JA, Faas M, Grüneboom A, Schürmann S, Friedrich O (2020) An advanced optical clearing protocol allows label-free detection of tissue necrosis via multiphoton microscopy in injured whole muscle. Theranostics 11(6): 2876-2891. (doi: 10.7150/thno.51558) [IF 11.600 (2021)]
  2. Taeger CD, Friedrich O, Horch RE, Drechsler C, Kengelbach-Weigand A, Wenzel C, Prantl L, Präbst K (2020) Tissue viability of free flaps after extracorporeal perfusion using a modified hydroxyethyl starch solution. J Clin Med 3: 3929. (doi: 10.3390/jcm9123929)
  3. Shafiee A, Cavalcanti AS, Saidy NT, Schneidereit D, Friedrich O, Ravichandran A, Pardo EJ, Hutmacher DW(2020) Convergence of 3D Printed Biomimetic Wound Dressings and Adult Stem Cell Therapy. Biomaterials 268: 120558. (doi: 10.1016/j.biomaterials.2020.120558)
  4. Carullo G, Mazzotta S, Koch A, Hartmann KM, Friedrich O, Gilbert DF, Vega-Holm M, Schneider-Stock R, Aiello F (2020) New oleoyl Hybrids of natural antioxidants: synthesis and in vitro evaluation as inducers of apoptosis in colorectal cancer cells. Antioxidants 9: 1077. (doi: 10.3390/antiox9111077)
  5. Weizel A, Distler D, Schneidereit D, Friedrich O, Bräuer L, Paulsen F, Detsch R, Boccaccini AR, Budday S, Seitz H (2020) Complex mechanical behavior of human articular cartilage and hydrogels for cartilage repair. Acta Biomater 113: 113-128. (doi: 10.1016/j.actbio.2020.10.025)
  6. Ritter P, Bye LJ, Finol-Urdaneta RF, Lesko C, Adams DJ, Friedrich O (2020) A method for high-content functional imaging of intracellular calcium responses in gelatin-immobilized non-adherent cells. Exp Cell Res 395: 112210. (doi: 10.1016/j.yexcr.2020.112210)
  7. Pollmann C*, Haug M*, Reischl B, Prölß G, Pöschel T, Rupitsch S, Clemen C, Schröder R, Friedrich O (2020) Growing old too early: skeletal muscle single fiber biomechanics in ageing R349P desmin knock-in mice using the MyoRobot technology. Int J Mol Sci 21(15): 5501. (doi: 10.3390/ijms21155501)
  8. Schwappacher R, Schink K, Sologub S, Dieterich W, Reljic D, Friedrich O, Herrmann HJ, Neurath MF, Zopf Y (2020) Physical activity and advanced cancer: Evidence of exercise-sensitive genes regulating prostate cancer cell proliferation and apoptosis. J Physiol 598.18: 3871-3889. (doi: 10.1113/JP279150)
  9. Distler T, Sulistio A, Schneidereit D, Friedrich O, Detsch R, Boccaccini A (2020) 3D Printed Oxidized Alginate-Gelatin Bioink Provides Guidance for C2C12 Muscle Precursor Cell Orientation and Differentiation via Shear Stress During Bioprinting. Biofabrication 12(4): 045005. (doi: 10.1088/1758-5090/ab98e4)
  10. Hazur J, Detsch R, Karakaya E, Kaschta J, Tessmar J, Schneidereit D, Friedrich O, Schubert D, Boccaccini A (2020) Improving alginate printability for biofabrication: establishment of a universal and homogeneous pre-crosslinking technique. Biofabrication 12(4): 045004. (doi: 10.1088/1758-5090/ab98e5)
  11. Fröhlich T, Mai C, Bogautdinov RP, Morozkina SN, Shavva AG, Friedrich O, Gilbert DF, Tsogoeva SB (2020) Synthesis of Tamoxifen-Artemisinin and Estrogen-Artemisinin Hybrids Highly Potent Against Breast and Prostate Cancer. Chem Med Chem 15(15): 1473-1479. (doi: 10.1002/cmdc.202000174)
  12. Kreiß L, Thoma OM, Dilipkumar A, Carle B, Longequeue P, Kunert T, Rath T, Hildner K, Neufert C, Vieth M, Neurath MF, Friedrich O, Schürmann S, Waldner MJ (2020) Label-free in vivo histopathology of experimental colitis via three-channel multiphoton endomicroscopy. Gastroenterology 159(3): 832-834.  (doi: 10.1053/j.gastro.2020.05.081)
  13. No YJ, Tarafder S, Reischl B, Ramaswamy Y, Dunstan C, Friedrich O, Lee C, Zreiqat H (2020) High-strength fiber-reinforced composite hydrogel scaffolds as biosynthetic tendon graft material. ACS Biomater Sci Eng 6: 1887-1898. (doi: 10.1021/acsbiomaterials.9b01716)
  14. Tolksdorf J, Horch RE, Grüner JS, Schmid R, Kengelbach-Weigand A, Schubert DW, Werner S, Schneidereit D, Friedrich O, Ludolph I (2020) Size matters-in vitro behaviour of human fibroblasts on textured silicone surfaces with different pore sizes. J Mater Sci Mater Med 31(2): 23. (doi: 10.1007/s10856-020-6360-5)
  15. Fey C, Betz J, Rosenbaum C, Kralisch D, Vielreicher M, Friedrich O, Zdzieblo D, Metzger M (2020) Bacterial nanocellulose as novel carrier for intestinal epithelial cells in drug delivery studies. Mat Sci Eng C (Biomater Adv) 109: 110613. (doi: 10.1016/j.msec.2019.110613)

  1. Steinmann S, Muenzner J, Ndreshkjana B, Geppert C, Eckstein M, Carle B, Bramsen J, Gasparini P, Friedrich O, Andersen C, Wang S, Eyuepoglu I, Baeuerle T, Hartmann A, Hampel C, Kemenes S, Schneider-Stock R (2019) DAPK1 loss gene signature triggers tumor invasion and tumor cell-ECM interaction in colorectal tumor cells. Cell Death Dis 10(12): 895. (doi: 10.1038/s41419-019-2122-z)
  2. Simon N, Sperber C, Voigtländer C, Born J, Gilbert DF, Seyferth S, Lee G, Kappes B, Friedrich O (2019) Improved stability of polyclonal antibodies: a case study with lyophilization-conserved antibodies raised against epitopes from the malaria parasite Plasmodium falciparum. Eur J Pharm Sci 142: 105086. (doi: 10.1016/j.ejps.2019.105086)
  3. Kreiß L, Hohmann M, Klämpfl F, Schürmann S, Dehghani F, Schmidt M, Friedrich O, Büchler L (2019) Diffuse reflectance spectroscopy and Raman spectroscopy for label-free molecular characterization and automated detection of human cartilage and subchondral bone. Sensor Actuat B-Chem 301: 127121. (doi: 10.1016/j.snb.2019.127121)
  4. Aschenbrenner D, Friedrich O, Gilbert DF (2019) 3D-printed lab-on-achip platform for chemical stimulation and parallel analysis of ion channel function. Micromachines 10: 00548. (doi: 10.3390/mi10080548)
  5. Kahl M, Gertig M, Hoyer P, Friedrich O, Gilbert DF (2019) Ultra-low-cost 3D bioprinting: Modification & application of an off-the-shelf desktop 3D-printer for biofabrication. Front Bioeng Biotechnol 7: 184. (doi: 10.3389/fbioe.2019.00184)
  6. Capci A, Lorion MM, Wang H, Simon N, Leidenberger M, Borges Silva MC, Moreira DRM, Zhu Y, Meng Y, Chen JY, Lee YM, Friedrich O, Kappes B, Wang J, Ackermann L, Tsogoeva SB (2019) Artemisinin-(Iso)Quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria. Angew Chem Int Ed 58: 13066-13079. (doi: 10.1002/anie.201907224)
  7. Lopez-Posadas R, Fastancz P, Martinez-Sanchez L del C, Panteleev-Ivlev J, Thonn V, Kisseleva T, Becker LS, Schulz-Kuhnt A, Zundler S, Wirtz S, Atreya R, Carle B, Friedrich O, Schürmann S, Waldner MJ, Neufert C, Brakebusch CH, Bergö MO, Neurath MF, Atreya I (2019) Inhibiting PGGT1B disrupts function of RHOA, resulting in T-cell expression of integrin α4β7 and development of colitis in mice. Gastroenterology 157: 1293-1309. (doi: 10.1053/j.gastro.2019.07.007)
  8. Haug M, Meyer C, Reischl B, Prölß G, Vetter K, Iberl J, Nübler S, Schürmann S, Rupitsch SJ, Heckel M, Pöschel T, Winter L, Herrmann H, Clemen CS, Schröder R, Friedrich O (2019) The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice. Sci Rep 9: 10769. (doi:  10.1038/s41598-019-46723-6)
  9. Friedrich O, Haug M, Reischl B, Prölß G, Kiriaev L, Head SI, Reid MB (2019) Single muscle fibre biomechanics and biomechatronics – the challenges, the pitfalls and the future. Int J Biochem Cell Biol 114: 105563. (doi: 10.1016/j.biocel.2019.105563)
  10. Haug M, Meyer C, Reischl B, Prölß G, Nübler S, Schürmann S, Schneidereit D, Heckel M, Pöschel T, Rupitsch SJ, Friedrich O (2019) MyoRobot 2.0: an advanced biomechatronics platform for automated, environmentally controlled skeletal muscle single fiber biomechanics assessment employing inbuilt real-time optical imaging. Biosens Bioelectron 138: 111284. (doi: 10.1016/j.bios.2019.04.052)
  11. Friedrich O, Merten AL, Schneidereit D, Guo Y, Schürmann S, Martinac B (2019) Stretch in Focus: 2D in-planar cell stretch systems for studies of cardiac mechano-signaling. Front Bioeng Biotechnol 7: 55. (doi: 10.3389/fbioe.2019.00055)
  12. Schmitt M, Friedrich O, Gilbert DF (2019) Portoporator©: A portable low-cost electroporation device for gene transfer to cultured cells in biomedical research, biotechnology and education. Biosens Bioelectron 131: 95-103. (doi: 10.1016/j.bios.2019.02.024)
  13. Pöttler M, Fliedner A, Bergmann J, Bui LK, Mühlberger M, Braun C, Graw M, Janko C, Friedrich O, Alexiou C, Lyer S (2019) Magnetic tissue engineering of the vocal fold: generation of 3D cell-constructs using superparamagnetic iron oxide nanoparticles. Tissue Eng Part A 25: 1470-1477. (doi: 10.1089/ten.tea.2019.0009)
  14. Li JJ, Dunstan CR, Entezari A, Li Q, Steck R, Saifzadeh S, Sandehpour A, Field JR, Akey A, Vielreicher M, Friedrich O, Roohani-Estefani SI, Zreiqat H (2019) A novel bone substitute with high bioactivity, strength and porosity for repairing large and load-bearing defects. Adv Healthcare Mater 8(8): e1801298. (doi: 10.1002/adhm.201801298)
  15. Dilipkumar A, Al-Shemmary A, Kreiß L, Cvecek C, Carlé B, Knieling F, Gonzales Menzes J, Thoma O-M, Schmidt M, Neurath MF,Waldner M, Friedrich O, Schürmann S (2019) Label-free multiphoton endomicroscopy for minimally invasive in vivo imaging. Adv Sci 6(8): 1801735. (doi: 10.1002/advs.201801735)
  16. Latronico N, Friedrich O (2019) Electrophysiological investigations of peripheral nerves and muscles: A method for looking at cell dysfunction in the critically ill patients. Crit Care 23: 33. (doi: 10.1186/s13054-019-2331-y)
  17. Karagöz AC, Leidenberger M, Hahn F, Friedrich O, Hampel F, Marschall M, Kappes B, Tsogoeva S (2019) Synthesis of new betulinic acid/betulin-derived dimers and Hybrids with potent antimalarial and antiviral activities. Bioorg Med Chem 27: 110-115. (doi: 10.1016/j.bmc.2018.11.018)
  18. Gilbert DF, Abolpour Mofrad S, Friedrich O, Wiest J (2018) Proliferation characteristics of cells cultured under periodic vs. static conditions. Cytotechnology 71(1): 443-452. (doi: 10.1007/s10616-018-0263-z)
  19. Schneidereit D, Schürmann S, Friedrich O (2019) PiezoGRIN: A highpressure chamber incorporating GRIN lenses for high-resolution 3D microscopy of living cells and tissues. Adv Sci 6(4): 180453. (doi: 10.1002/advs.201801453)

  1. Scheibe K, Kersten C, Schmied A, Vieth M, Primbs T, Carlé B, Knieling F, Claussen J, Klimowicz AC, Zheng J, Baum P, Meyer S, Schürmann S, Friedrich O, Waldner MJ, Rath T, Wirtz S, Kollias G, Ekici AB, Atreya R, Raymond EL, Mbow ML, Neurath MF, Neufert C (2018) Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice with Chronic Intestinal Inflammation. Gastroenterology 156(4): 1082-107.
  2. Fröhlich T, Kiss A, Wolfling J, Mernyak E, Kulmany A, Minorics R, Zupko I, Leidenberger M, Friedrich O, Kappes B, Hahn F, Marschall M, Schneider G, Tsogoeva S (2018) Synthesis of artemisinin-estrogen hybrids highly active against HCMV, P. falciparum, cervical and breast cancer. ACS Med Chem Lett 9: 1128-1133. (doi: 10.1021/acsmedchemlett.8b00381)
  3. Schneidereit D, Nübler S, Prölß G, Reischl B, Schürmann S, Müller OJ, Friedrich O (2018) Optical prediction of single muscle fibre force production using a combined biomechatronics-Second Harmonic Generation Imaging Approach. Light Sci Appl 7: 79. (doi: 10.1038/s41377-018-0080-3)
  4. Ugele M, Weniger M, Stanzel M, Bassler M, Krause S, Friedrich O, Hayden O, Richter L (2018) Label-free high-throughput leukemia detection by holographic microscopy. Adv Sci 5(12): 1800761. (doi: 10.1002/advs.201800761)
  5. Reiling SJ, Krohne G, Friedrich O, Geary T, Rohrbach P (2018) Chloroquine exposure triggers distinct cellular responses in sensitive versus resistant Plasmodium falciparum parasites. Sci Rep 8(1): 11137. (doi: 10.1038/s41598- 018-29422-6)
  6. Vielreicher M, Kralisch D, Völkl S, Sternal F, Arkudas A, Friedrich O (2018) Bacterial nanocellulose stimulates mesenchymal stem cell expansion and formation of stable collagen-I networks as a novel biomaterial in tissue engineering. Sci Rep 8: 9401. (doi: 10.1038/s41598-018-27760-z)
  7. Ugele M, Weniger M, Leidenberger M, Huang Y, Bassler M, Friedrich O, Kappes B, Hayden O (2018) Label-free, high-throughput detection of P. falciparum infection in sphered erythrocytes with digital holographic microscopy. Lab Chip 18: 1704-1712. (doi: 10.1039/c8lc00350e)
  8. Karagöz AC, Reiter C, Seo EJ, Gruber L, Hahn F, Leidenberger M, Klein V, Hampel F, Friedrich O, Marschall M, Kappes B, Efferth T, Tsogoeva SB (2018) Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin. Bioorg Med Chem 26: 3610-3618. (doi: 10.1016/j.bmc.2018.05.041)
  9. Li JJ, Akey A, Dunstan C, Vielreicher M, Friedrich O, Bell D, Zreiqat H (2018) Effects of material-tissue interactions on bone regeneration outcomes using baghdadite implants in a large animal model. Adv Healthcare Mater 1800218. (doi: 10.1002/adhm.201800218)
  10. Scharin-Mehlmann M, Häring A, Rommel M, Dirnecker T, Friedrich O, Frey L, Gilbert DF (2018) Nano- and micro-patterned S-, H- and X-PDMS for cell-based applications: Comparison of wetability, roughness and cell-derived parameters. Front Bioeng Biotechnol 6: 51. (doi: 10.3389/fbioe.2018.00051)
  11. Schneidereit D, Tschernich J, Friedrich O, Scharin-Mehlmann M, Gilbert DF (2018) 3D printed reusable cell culture chamber with integrated electrodes for electrical stimulation and parallel microscopic evaluation. 3D Print Addit Manuf 5(2): 115-125. (doi: 10.1089/3dp.2017.0103)
  12. Fröhlich T, Hahn F, Belmudes L, Leidenberger M, Friedrich O, Kappes B, Coute Y, Marschall M, Tsogoeva SB (2018) Synthesis of artemisinin-derived di/tri-mers and dendrimers, investigation of their activity against P. falciparum and cytomegalovirus, and insights into their mechanisms of action. Chem Eur J 24: 8103-8113. (doi: 10.1002/chem.201800729)
  13. Reisbeck M, Richter L, Helou MJ, Arlinghaus S, Anton B, van Dommelen I, Nitzsche M , Baßler M, Kappes B, Friedrich O, Hayden O (2018) Hybrid integration of scalable mechanical and magnetophoretic focusing for magnetic flow cytometry. Biosens Bioelectron 109: 98-108. (doi: 10.1016/j.bios.2018.02.046)
  14. Simon N, Kappes B, Friedrich O (2018) Quantification of human complement factor H binding to asexual malaria blood stages by an enzyme-linked immunosorbent assay. Vaccines 36: 1545-1547. (doi: 10.1016/j.vaccine.2018.01.080)
  15. Friedrich O, Diermeier S, Larsson L (2018) Weak by the Machines: Muscle Motor Protein Dysfunction – a side Effect of Intensive Care Unit Treatment. Acta Physiologica 222: 1-14. (doi: 10.1111/apha.12885)
  16. Fröhlich R, Reiter C, Saeed M, Hutterer C, Hahn F, Leidenberger M, Friedrich O, Kappes B, Marschall M, Efferth T, Tsogoeva S (2018) Synthesis of Thymoquinone-Artemisinin hybrids: new potent antileukemia , antiviral and antimalarial agents. ACS Med Chem Lett 9(6): 534-539. (doi: 10.1021/acsmedchemlett.7b00412)
  17. Haug M, Reischl B, Prölß G, Pollmann C, Buckert T, Keidel C, Schürmann S, Hock M, Rupitsch S, Heckel M, Pöschel T, Scheibel T, Haynl C, Kiriaev L, Head SI, Friedrich O (2018) The MyoRobot: a novel automated biomechatronics system to assess voltage/Ca2+ biosensors and active/passive biomechanics in muscle and biomaterials. Biosens Bioelectron 102: 589-599. (doi: 10.1016/j.bios.2017.12.003)
  18. Kravic B, Harbauer AB, Romanello V, Simeone L, Vöglte FN, Kaiser T, Straubinger M, Huraskin D, Böttcher M, Cerqua C, Martin ED, Poveda-Huertes D, Buttgereit A, Rabalski A, Heuss D, Rudolf R, Friedrich O, Lichtfield D, Marber M, Salviati L, Mougiakakos D, Neuhuber W, Sanrdi M, Meisinger C, Hashemolhosseini S (2017) In mammalian skeletal muscle phosphorylation of Tom22 by protein kinase CK2 controls mitophagy. Autophagy 14(2): 311-335.  (doi: 10.1080/15548627.2017.1403716)

  1. Taeger CD, Friedrich O, Horch RE, Drechsler C, Weigand A, Hopf F, Geppert CI, Münch F, Birkholz T, Wenzel C, Geis S, Prantl L, Buchholz R, Präbst K (2017) Extracorporeal perfusion – reduced to a one-way infusion. Clin Hemorheol Microcirc 79(2): 257-267.
  2. Friedrich O, Schneidereit D, Nikolaev YA, Nikolova-Krstevski V, Schürmann S, Wirth-Hücking A, Merten AL, Fatkin D, Martinac B (2017) Adding Dimension to cellular mechanotransduction: Advances in biomedical engineering of multiaxial cell-stretch systems and their application to cardiovascular biomechanics and mechano-signaling. Prog Biophys Mol Biol 130: 170-191. (doi: 10.1016/j.pbiomolbio.2017.06.011)
  3. Diermeier S, Buttgereit A, Schürmann S, Winter L, Xu H, Murphy RM, Clemen CS, Schröder R, Friedrich O (2017) Pre-aged remodelling of myofibrillar architecture in skeletal muscle expressing R349P mutant desmin. Neurobiol Aging 58: 77-87. (doi: 10.1016/j.neurobiolaging.2017.06.001)
  4. Nikolova-Krstevski V,Wagner S, Yan Yu Z, Cox CD, Cvetkovska J, Hill AP, Huttner IG, Benson V,Werdich A, MacRae C, Feneley MP, Friedrich O, Martinac B, Fatkin D (2017) Endocardial TRPC6 channels act an atrial mechanosensors and load-dependent modulators of endocardial/myocardial cross-talk. JACC Basic Transl Sci 2(5): 575-590. (doi: 10.1016/j.jacbts.2017.05.006)
  5. Vielreicher M, Friedrich O (2017) Assessment of Population and ECM Production Using Multiphoton Microscopy as an Indicator of Cell Viability. Meth Mol Biol 1601: 243-255. (doi: 10.1007/s15002-016-0984-3)
  6. Friedrich O, Head SI (2017) Quantitative Ratiometric Ca2+ Imaging to Assess Cell Viablity. Meth Mol Biol 1601: 171-193. (doi: 10.1007/978-1-4939-6960-914) [IF 1.372 (2021)]
  7. Gilbert DF, Friedrich O (Editors) (2017) Cell Viability Assays, Methods and Protocols. Meth Mol Biol, Methods in Springer New York, 2017, vol. 1601. (doi: 10.1007/978-1-4939-6960-9)
  8. Fröhlich T, Reiter C, Ibrahim M, Beutel J, Hutterer C, Zeittr¨ager I, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Efferth T, Marschall M, Tsogoeva S (2017) Synthesis of Novel Hybrids of Quinazoline and Artemisinin with High Activities Against Plasmodium falciparum, Human Cytomegalovirus and Leukemia Cells. ACS Omega 2: 2422-2431. (doi: 10.1021/acsomega.7b00310)
  9. Diermeier S, Iberl J, Vetter K, Haug M, Pollmann, Reischl B, Buttgereit A, Schürmann S, Spörrer M, Goldmann WH, Fabry B, Elhamine F, Stehle R, Pfitzer G, Winter L, Clemen CS, Herrmann H, Schröder R, Friedrich O (2017) Early signs of architectural and biomechanical failure in isolated myofibers and immortalized myoblasts from desmin-mutant knock-in mice. Sci Rep 7: 1391. (doi: 10.1038/s41598-017-01485-x)
  10. Bock CM, Parameshwarappa G, Bauer W, Hutterer C, Leidenberger M, Friedrich O , Marschall M, Kappes B, Tsogoeva S (2017) Deeper insight into the sixstep domino reaction of aldehyde with maloninitrile and evaluation of antiviral and antimalarial activities of highly functionalized domino products. Chemistry Open 6: 364-374. (doi: 10.1002/open.201700005)
  11. Abolpour Mofrad S, Kuenzel K, Friedrich O, Gilbert DF (2017) On the generation of efficient methodologies for cell-based toxicity screening by comparative protocol analysis and optimization. Single Cell Biology 6: 1 (Commentary).
  12. Larsson L, Friedrich O (2017) Critical illness myopathy (CIM) and ventilatorinduced diaphragm muscle dysfunction (VIDD): acquired myopathies affecting contractile proteins. Compr Physiol 7: 105-112. (doi: 10.1002/cphy.c150054)
  13. Schneidereit D, Kraus L, Meier J, Friedrich O, Gilbert DF (2017) Step-bystep guide to building an inexpensive 3D printed motorized positioning stage for automated high-content screening microscopy. Biosens Bioelectron 92: 472-481. (doi: 10.1016/j.bios.2016.10.078)

  1. Gilbert DF, Stebbing MJ, Kuenzel K, Murphy R, Zacharewicz E, Buttgereit A, Stokes L, Adams DJ, Friedrich O (2016) Store-operated Ca2+ entry (SOCE) and purinergic receptor-mediated Ca2+ homeostasis in murine BV2 microglia cells: early cellular responses to ATP-mediated microglia activation. Front Mol Neurosci 9: 111. (doi: 10.3389/fnmol.2016.00111)
  2. Schneidereit D, Vass H, Reischl B, Allen RJ, Friedrich O (2016) Calcium sensitive fluorescent dyes Fluo-4 and Fura Red under pressure: behaviour of fluorescence and buffer properties under hydrostatic pressures up to 200 MPa. PLoS One 11(10): e0164509. (doi: 10.1371/journal.pone.0164509)
  3. Vielreicher M, Friedrich O (2016) Nichtinvasive Hochleistungstechnik zur Gewebeuntersuchung. Multiphotonen-Mikroskopie stellt Kollagen-I-Netzwerk in Knochen dar. Orthopädie & Rheuma 19(5): 38-43.
  4. Olah T, Bodnar D, Toth A, Vincze J, Fodor J, Reischl B, Kovascs A, Ruzsnavszky O, Dienes B, Szentesi P, Friedrich O, Csernoch L (2016) Cannabinoid signalling inhibits sarcoplasmic Ca2+ release and regulates excitation-contraction coupling in mammalian skeletal muscle. J Physiol 594: 7381-7398. (doi: 10.1113/JP272449)
  5. Reisbeck M, Helou MJ, Richter L, Kappes B, Friedrich O, Hayden O (2016) Magnetic fingerprints of rolling cells for quantitative flow cytometry in whole blood. Sci Rep 6: 32838. (doi: 10.1038/srep32838)
  6. Abolpour Mofrad S, Kuenzel K, Friedrich O, Gilbert DF (2016) Optimizing neuronal differentiation of human pluripotent NT2 stem cells in monolayer cultures. Dev Growth Differ 58(8): 664-676. (doi: 10.1111/dgd.12323)
  7. Spitzer P, Condic Mateja, Herrmann M, Oberstein TJ, Scharin-Mehlmann M, Gilbert DF, Friedrich O, Grömer T, Kornhuber J, Lang R, Maler JM (2016) Amyloidogenic amyloid β-peptide variants induce microglial agglutination and exert antimicrobial activity. Sci Rep 6: 3228. (doi: 10.1038/srep32228)
  8. Chernavskaia O, Heuke S, Vieth M, Friedrich O, Schürmann S, Atreya R, Stallmach A, Neurath MF, Waldner M, Petersen I, Schmitt M, Bocklitz T, Popp J (2016) Beyond endoscopic assessment in inflammatory bowel disease: real-time histology of disease activity by non-linear multimodal imaging. Sci Rep 6: 29239. (doi: 10.1038/srep29239)
  9. Kuenzel K, Friedrich O, Gilbert DF (2016) A recombinant human pluripotent stem cell line stably expressing halide-sensitive YFP-I152L for GABAAR and GlyR-targeted high-throughput drug screening and toxicity testing. Front Mol Neurosci 9: 51. (doi: 10.3389/fnmol.2016.00051)
  10. Dakhil H, Gilbert DF, Malhotra D, Limmer A, Engelhardt H, Amtmann A, Hansmann J, Hübner H, Buchholz R, Friedrich O, Wierschem A (2016) Measuring average rheological quantities of cell monolayers in the linear viscoelastic regime. Rheol Acta 55: 527-536. (doi: 10.1007/s00397-016-0936-5)
  11. Schürmann S, Wagner S, Herlitze S, Fischer C, Gumbrecht S, Wirth-Hücking A, Prölß G, Lautscham LA, Goldmann WH, Nikolova-Krstevski V, Martinac B, Friedrich O (2016) The IsoStretcher: An isotropic cell stretch device to study mechanical biosensor pathways in living cells. Biosens Bioelectron 81: 363-372. (doi: 10.1016/j.bios.2016.03.015)
  12. Taeger CD, Friedrich O, Drechsler C, Weigand A, Hobe F, Geppert CI, Münch F, Birkholz T, Buchholz R, Horch RE, Präbst K (2016) Hydroxyethyl starch solution for extracorporeal tissue perfusion. Clin Hemorheol Microcirc 64(1): 91-103. (doi: 10.3233/CH-162049)
  13. Menzner AK, Abolpour Mofrad S, Friedrich O, Gilbert DF (2015) Towards in vitro DT/DNT testing: assaying chemical susceptibility in early differentiating NT2 cells. Toxicology 338: 69-76. (doi: 10.1016/j.tox.2015.10.007)
  14. Vielreicher M, Gellner M, Rottensteiner U, Horch R, Arkudas A, Friedrich O (2015) Multiphoton microscopy analysis of extracellular collagen-I network formation by mesenchymal stem cells. J Tissue Eng Regen Med 11: 2104–2115. (doi: 10.1002/term.2107)
  15. Wagner S, Schürmann S, Hein S, Schüttler J, Friedrich O (2015) Septic cardiomyopathy in rat LPS-induced endotoxemia: relative contribution of cellular diastolic Ca2+ removal pathways, myofibrillar biomechanics properties and action of the cardiotonic drug levosimendan. Basic Res Cardiol 110(5): 507. (doi: 10.1007/s00395-015-0507-4)
  16. Auernheimer V, Lautscham LA, Leidenberger M, Friedrich O, Kappes B, Fabry B, Goldmann WH (2015) Vinculin phosphorylation at residues Y100 and Y1065 is required for cellular force transmission. J Cell Sci 128(18): 3435-3443. (doi: 10.1242/jcs.172031)
  17. Reiter C, Fröhlich T, Gruber L, Hutterer C, Marschall M, Voigtländer C, Friedrich O, Kappes B, Efferth T, Tsogoeva S (2015) Highly potent artemisinin derived dimers and trimers: synthesis and evaluation of their antimalaria, antileukemia and antiviral activities. Bioorg Med Chem 23(17): 5452-5458. (doi: 10.1016/j.bmc.2015.07.048)
  18. Taeger CD, Friedrich O, Dragu A, Weigand A, Hobe F, Drechsler C, Arkudas A, Münch F, Buchholz R, Schramm A, Birkholz T, Horch RE, Präbst K (2015) Assessing viability of extracorporeal preserved muscle transplants using external field stimulation: a novel tool to improve methods prolonging bridgeto-transplantation time. Sci Rep 5: 11956. (doi: 10.1038/srep11956)
  19. Ritterhoff, Völkers M, Seitz A, Spaich K, Gao E, Peppel K, Pleger S, Zimmermann W, Friedrich O, Fink R, Koch W, Katus H, Most P (2015) S100A1 DNA-based inotropic therapy protects against pro-arrhythmic ryanodine receptor 2 dysfunction. Mol Ther 23(8): 1320-1330. (doi: 10.1038/mt.2015.93)
  20. Sinner B, Friedrich O, Lindner R, Bundscherer A, Graf BM (2015) Long-term NMDA receptor inhibition affects NMDA receptor expression and alters glutamatergic activity in developing rat hippocampal neurons. Toxicology 333: 147-155. (doi: /10.1016/j.tox.2015.04.017)
  21. Friedrich O, Reid MB, Van den Berghe G, Vanhorebeek I, Hermans G, Rich MM, Larsson L (2015) The sick and the weak: Neuropathies/myopathies in the critically ill – cellular mechanisms of complex disease entities. Physiol Rev 95(3): 1025-1109. (doi: 10.1152/physrev.00028.2014)
  22. Reiter C, Fröhlich T, Zeino M, Marschall M, Bahsi H, Leidenberger M, Friedrich O, Kappes B, Hampel F, Efferth T, Tsogoeva SB (2015) New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids. Eur J Med Chem 97: 164-172. (doi: 10.1016/j.ejmech.2015.04.053)
  23. Clemen C, Stöckigt F, Strucksberg K-H, Chevessier F, Winter L, Schütz J, Bauer R, Thorweihe JM, Wenzel D, Schlötzer-Schrehardt U, Rasche V, Krsmanovic P, Katus H, Rottbauer W, Just S, Müller O, Friedrich O, Meyer R, Herrmann H, Schrickel JW, Schröder R (2015) The toxic effects of R350P mutant desmin in striated muscle of man and mouse. Acta Neuropathol 129(2): 297-315. (doi: 10.1007/s00401-014-1363-2)
  24. Head SI, Chan S, Houweling PJ, Quinlan KGR, Murphy R,Wagner S, Friedrich O, North KN (2015) Altered Ca2+ kinetics associated with α-actinin-3 deficiency may explain positive selection for ACTN3 null allele in human evolution. PLoS Genet 11(2): e1004862. (doi: 10.1371/journal.pgen.1004862)
  25. Walzik MP, Vollmar V, Lachnit T, Dietz H, Haug S, Bachmann H, Fath M, Aschenbrenner D, Abolpour Mofrad S, Friedrich O, Gilbert DF (2015) A portable low-cost long-term live-cell imaging platform for biomedical research and education. Biosens Bioelectron 64: 639-649. (doi: 10.1016/j.bios.2014.09.061)
  26. Friedrich O, Reiling SJ, Wunderlich J, Rohrbach P (2014) Assessment of Plasmodium falciparum PfMDR1 transport rates using Fluo-4. J Cell Mol Med 18(9): 1851-1862. (doi: 10.1111/jcmm.12313)
  27. Buttgereit A, Weber C, Friedrich O (2014) A novel quantitative morphometry approach to assess regeneration in dystrophic skeletal muscle. Neuromuscul Disord 24(7): 596-603. (doi: 10.1016/j.nmd.2014.04.011)
  28. Friedrich O (2014) ‘Set the controls…’ – phenotype matching beyond genetics in muscular dystrophy. Exp Physiol 99.4: 638-639. (doi: 10.1113/expphysiol. 2014.077933)
  29. Friedrich O, Yi B, Edwards JN, Reischl B, Wirth-Hücking A, Buttgereit A, Lang R, Weber C, Polyak F, Liu I, von Wegner F, Cully TR, Lee A, Most P, Völkers M (2014) Interleukin-1α reversibly inhibits skeletal muscle ryanodine  receptor: a novel mechanism for critical illness myopathy? Am J Respir Cell Mol Biol 50(6): 1096-1106. (doi: 10.1165/rcmb.2013-0059OC)
  30. Taskin S, Stumpf VI, Bachmann J,Weber C, Martignoni ME, Friedrich O (2014) Motor protein function in skeletal abdominal muscle of cachectic cancer patients. J Cell Mol Med 18(1): 69-79. (doi: 10.1111/jcmm.12165)
  31. Lang NR, Metzner C, Krauss P, Schürmann S, Lange J, Aifantis KE, Friedrich O, Fabry B (2013) Estimating the 3D pore size distribution of biopolymer  networks from directionally biased data. Biophys J 105: 1967-1975. (doi: 10.1016/j.bpj.2013.09.038)
  32. Vielreicher M, Schürmann S, Buttgereit A, Schmidt M, Detsch R, Boccaccini A, Friedrich O (2013) Taking a deep look: modern microscopy technologies to optimize the design and functionality of biocompatible scaffolds for tissue engineering in regenerative medicine. J R Soc Interface 10(86): 20130263. (doi: 10.1098/rsif.2013.0263)
  33. Schürmann S, Foersch S, Atreya R, Neumann H, Friedrich O, Neurath MF, Waldner M (2013) Label-free imaging of inflammatory bowel disease using multiphoton microscopy. Gastroenterology 145(3): 514-516. (doi: 10.1053/j.gastro.2013.06.054)
  34. Jung J, Weisenburger S, Albert S, Gilbert DF, Friedrich O, Eulenburg V, Kornhuber J, Groemer TW (2013) On the performance of scientific cameras with different sensor types in measuring dynamic processes in fluorescence microscopy. Microsc Res Tech 76(8): 835-843. (doi: 10.1002/jemt.22236)
  35. Buttgereit A, Weber C, Garbe C, Friedrich O (2013) From chaos to split ups – SHG microscopy reveals a specific remodeling mechanism in aging dystrophic muscle. J Pathol 229(3): 477-485.(doi: 10.1002/jemt.22236) (doi: 10.1002/path.4136)
  36. Wagner S, Knipp S, Weber C, Hein S, Schinkel S, Walther A, Bekeredjian R, Müller OJ, Friedrich O (2012) The heart in Duchenne muscular dystrophy: early detection of contractile performance alteration. J Cell Mol Med 16(12): 3028-3036. (doi: 10.1111/j.1582-4934.2012.01630.x)
  37. Friedrich O, Wagner S, Battle AR, Schürmann S, Martinac B (2012) Mechano-regulation of the beating heart at the cellular level – Mechanosensitive channels in normal and diseased heart. Prog Biophys Mol Biol 110: 226-238. (doi: 10.1016/j.pbiomolbio.2012.08.009)
  38. Cully TR, Edwards JN, Friedrich O, Stephenson DG, Murphy RM, Launikonis BS (2012) Changes in plasma membrane CaATPase (PMCA) and stromal interacting molecule 1 (STIM1) expression levels for Ca2+ signaling in dystrophic mdx mouse muscle. Am J Physiol Cell Physiol 303(5): C567-C576. (doi: 10.1152/ajpcell.00144.2012)
  39. Garbe C, Buttgereit A, Schürmann S, Friedrich O (2012) Automated multi-scale morphometry of muscle disease from second-harmonic generation microscopy using tensor based image processing. IEEE Trans Biomed Eng 59(1): 39-44. (doi: 10.1109/TBME.2011.2167325)
  40. Sinner B, Friedrich O, Zausig Y, Bein T, Graf BM (2011) Toxic effects of midazolam on differentiating neurons in vitro as a consequence of suppressed neuronal Ca(2+)-oscillations. Toxicology 290(1): 96-101. (doi: 10.1016/j.tox.2011.08.022)
  41. Sinner B, Friedrich O, Zink W, Zausig Y, Graf BM (2011) The toxic effects of S(+)-Ketamine on differentiating neurons in vitro as a consequence of suppressed neuronal Ca2+ oscillations. Anesth Analg 113(5): 1161-1169. (doi: 10.1213/ANE.0b013e31822747df)
  42. Mohl MC, Iismaa SE, Xiao XH, Friedrich O,Wagner S, Nikolova-Krstevski V, Wu J, Yu ZY, Feneley M, Fatkin D, Allen DG, Graham RM (2011) Regulation of murine cardiac contractility by activation of α1A-adrenergic receptoroperated Ca2+ entry. Cardiovasc Res 91(2): 310-319. (doi: 10.1093/cvr/cvr081)
  43. Völkers M,Weidenhammer C, Herzog N, Qiu G, Spaich K, vonWegner F, Peppel K, Müller OJ, Schinkel S, Rabinowitz JE, Hippe HJ, Brinks H, Katus HA, Koch WJ, Eckhart AD, Friedrich O*, Most P* (2011) The inotropic peptide βARKct improves βAR responsiveness in normal and failing cardiomyocytes through Gβγ-mediated L-type calcium current disinhibition. Circ Res 108(1): 27-39. (doi: 10.1161/CIRCRESAHA.110.225201)
  44. Friedrich O (2010) Pressure, the nervous system and ion channels: are humans too complicated? Undersea Hyperbar Med 37(5): 241-244.
  45. Schürmann S, von Wegner F, Fink RH, Friedrich O, Vogel M (2010) Second harmonic generation microscopy probes different states of motor protein interaction in myofibrils. Biophys J 99(6): 1842-1851. (doi: 10.1016/j.bpj.2010.07.005)
  46. Edwards JN, Murphy RM, Cully TR, v Wegner F, Friedrich O, Launikonis BS (2010) Ultra-rapid activation and deactivation of store-operated Ca2+ entry in skeletal muscle. Cell Calcium 47(5): 458-467. (doi: 10.1016/j.ceca.2010.04.001)
  47. Edwards JN, Friedrich O, Cully TR, v Wegner F, Murphy RM, Launikonis BS (2010) Upregulation of store-operated Ca2+ entry in dystrophic mdx mouse muscle. Am J Physiol Cell Physiol 299(1): C42-C50. (doi: 10.1152/ajpcell. 00524.2009)
  48. Friedrich O (2010) One arm is enough, two might actually be worse. Exp Physiol 95(5): 607-608. (doi: 10.1113/expphysiol.2010.052621)
  49. Völkers M, Salz M, Herzog N, Frank D, Dolatabadi N, Frey N, Gude N, Friedrich O, Koch WJ, Katus HA, Sussman MA, Most P (2010) Orai1 and Stim1 regulates normal and hypertrophic growth in cardiomyocytes. J Mol Cell Cardiol 48(6): 1329-1334. (doi: 10.1016/j.yjmcc.2010.01.020)
  50. Friedrich O, Fink RHA, v Wegner F (2010) New factors contributing to dynamic calcium regulation in the skeletal muscle triad – a crowded place. Biophys Rev 2: 29-38. (doi: 10.1007/s12551-009-0027-2)
  51. Friedrich O, Both M,Weber C, Schürmann S, Teichmann MDH, vWegner F, Fink RHA, Vogel M, Chamberlain JS, Garbe C (2010) Microarchitecture is severely compromised but motor protein function is preserved in dystrophic mdx skeletal muscle. Biophys J 98: 606-616. (doi: 10.1016/j.bpj.2009.11.005)
  52. Friedrich O, Hund E, v Wegner F (2010) Enhanced muscle shortening and impaired Ca(2+) channel function in an acute septic myopathy model. J Neurol 257(4): 546-555. (doi: 10.1007/s00415-009-5362-5)
  53. Friedrich O (2010) Muscle function and high hydrostatic pressures. Cellular  mechanisms and implications for taxonomic environmental locomotion. In: Comparative High Pressure Biology. P. Sebert (ed.), Science Publishers Inc., Enfield, USA, pp.211-249.